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KMID : 0363620160370020119
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Journal of Korean Oriental Medicine
2016 Volume.37 No. 2 p.119 ~ p.124
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A Severe Hepatotoxicity by Antituberculosis Drug, and its Recovery in Oriental Hospital
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Son Chang-Gue
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Abstract
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Objectives: To demonstrate a clinical course and feature of a female patient with a severe liver injury (DILI) during antituberculosis treatment for her intestinal tuberculosis, whom traditional Korean medicine completely recovered.
Methods: A female patient with diagnosed as DILI by antituberculosis drugs had been treated with herbal drugs; and then the clinical outcome and biochemical parameters had been monitored.
Result: A 45-year old female had taken antituberculosis drugs for about 2 months, and complained severe abdominal discomfort and dyspepsia. The RUCAM score was 10, which met the criteria for DILI (AST 584 IU/L, ALT 1212 IU/L, ALP 100 IU/L, and GGT 161 IU/L, total bilirubin 0.9 mg/dL). She had been treated with herbal drugs and acupuncture as inpatient and outpatient, and then her symptoms had been completely recovered with normalization of hepatic enzymes.
Conclusion: This report provides a clinical characteristic for a severe hepatotoxicity induced by antituberculosis drugs, and showed an example of TKM-based application.
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KEYWORD
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Antituberculosis drug, Drug-induced liver injury, Traditional Korean medicine, Herbal medicine
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